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Alexander
DOINIKOV

Physics Chemistry Acoustics Medical - Belarus

Contact details

Research topics

PROJECT

ACOUSTREAM: Acoustic microstreaming as a tool of biomedical technologies

Cancer is a major health challenge of our society, with one in three persons being diagnosed with cancer during their lifetime. The deadliest cancers are lung, breast, bowel and prostate cancers. The reason is their high resistance to conventional treatment like chemotherapy. One of the major aims of cancer research is to increase the cytotoxic potential of chemotherapeutic drugs and their efficacy. Possible ways are to increase drug concentration in cancer cells and to increase drug penetration in the tumor bulk. However, increasing drug concentration in cancer cells and tumors is a challenge problem as the cell membrane isolates cells from chemo and prevents the penetration of drugs from the bloodstream into the tumor bulk.
To improve the delivery of drugs into cells, ultrasonically induced microbubble cavitation is applied. This process is called sonoporation. Cavitation-induced bioeffects are recognized as a key player in a broad range of biomedical applications such as blood-brain barrier opening, ultrasound neurostimulation and cell membrane poration. In such applications, a key requirement is to avoid microbubble-induced cell lysis or hemorrhage in tissue. Huge efforts are currently devoted to the development of new ultrasound techniques free of undesired effects. Liquid vortex flows generated by acoustically driven microbubbles, called acoustic microstreaming, which can exert necessary shear stresses on cells, are considered as a very promising technique.

This project aims at theoretical and experimental studies of acoustic microstreaming in the context of biomedical applications. It is planned to develop analytical models and to perform numerical simulations that will then be subjected to experimental verification. Results of the project will provide a deeper insight into the mechanism of the sonoporation-based targeted drug delivery as well as will contribute to the development of other applications using capabilities of acoustic microstreaming.

Activities / Resume

BIOGRAPHY

Alexander A. Doinikov received his Ph.D. degree in theoretical physics from the Belarus State University in 1990. In 1997, he received the degree of Doctor of Science in Physics and Mathematics from the National Academy of Sciences of Belarus.
From 1983 to 1991, he worked as a research engineer and a junior research scientist at the Institute of Applied Physics Problems of the Belarus State University. From 1991 to 1993, he worked as a senior research scientist in the Department of Applied Mathematics of the same university. Since 1993 Alexander Doinikov has been working as a senior research scientist and then (since 1998) as a principal research scientist at the Research Institute for Nuclear Problems of the Belarus State University. He worked as an invited scientist at the University of Patras (Greece), the University of Tours (France), the University of Grenoble (France), the University of Lyon (France) and the University of Zurich (Switzerland). His research interests focus on physical acoustics and medical ultrasonics.
 

BIBLIOGRAPHY

  • A. A. Doinikov, S. Cleve, G. Regnault, C. Mauger and C. Inserra, “Acoustic microstreaming produced by nonspherical oscillations of a gas bubble. I & II,” Phys. Rev. E 100(3), 033104, 033105 (2019).
  • A. A. Doinikov, P. Thibault and P. Marmottant, “Acoustic streaming induced by two orthogonal ultrasound standing waves in a microfluidic channel,” Ultrasonics 87, 7-19 (2018).
  • A. A. Doinikov, B. Dollet and P. Marmottant, “Model for the growth and the oscillation of a cavitation bubble in a spherical liquid-filled cavity enclosed in an elastic medium,” Phys. Rev. E 97(1), 013108 (2018).
  • A. A. Doinikov, P. Thibault and P. Marmottant, “Acoustic streaming in a microfluidic channel with a reflector: Case of a standing wave generated by two counterpropagating leaky surface waves,” Phys. Rev. E 96(1), 013101 (2017).
  • A. A. Doinikov and A. Bouakaz, “Microstreaming generated by two acoustically induced gas bubbles,” J. Fluid Mech. 796, 318-339 (2016).
  • A. A. Doinikov, F. Mekki-Berrada, P. Thibault and P. Marmottant, “Lamb-type waves generated by a cylindrical bubble oscillating between two planar elastic walls,” Proc. R. Soc. A 472(2188), 20160031 (2016).
  • A. A. Doinikov and A. Bouakaz, “Interaction of an ultrasound-activated contrast microbubble with a wall at arbitrary separation distances,” Phys. Med. Biol. 60(20), 7909-7925 (2015).
  • A. A. Doinikov and A. Bouakaz, “Theoretical model for coupled radial and translational motion of two bubbles at arbitrary separation distances,” Phys. Rev. E 92(4), 043001 (2015).
  • A. A. Doinikov, P. S. Sheeran, A. Bouakaz and P. A. Dayton, “Vaporization dynamics of volatile perfluorocarbon droplets: A theoretical model and in vitro validation,” Med. Phys. 41(10), 102901 (2014).
  • A. A. Doinikov, A. Novell, J.-M. Escoffre and A. Bouakaz, “Encapsulated bubble dynamics in imaging and therapy,” in Bubble Dynamics and Shock Waves, edited by C. F. Delale (Berlin Heidelberg, Springer-Verlag, 2013), pp. 259-289.
  • A. A. Doinikov, L. Aired and A. Bouakaz, “Dynamics of a contrast agent microbubble attached to an elastic wall,” IEEE Trans. Med. Imag. 31(3), 654-662 (2012).
  • A. A. Doinikov and A. Bouakaz, “Review of shell models for contrast agent microbubbles,” IEEE Trans. Ultrason. Ferroelect. Freq. Contr. 58(5), 981-993 (2011).
  • A. A. Doinikov, J. F. Haac, and P. A. Dayton, “Modeling of nonlinear viscous stress in encapsulating shells of lipid-coated contrast agent microbubbles,” Ultrasonics 49(2), 269-275 (2009).
  • A. A. Doinikov and P. A. Dayton, “Maxwell rheological model for lipid-shelled ultrasound microbubble contrast agents,” J. Acoust. Soc. Am. 121(6), 3331-3340 (2007).
  • A. A. Doinikov, “Bjerknes forces and translational bubble dynamics,” in Bubble and Particle Dynamics in Acoustic Fields: Modern Trends and Applications, edited by A. A. Doinikov (Research Signpost, Trivandrum, Kerala, India, 2005), pp. 95-143, ISBN: 81-7736-284-4.
  • A. A. Doinikov, “Acoustic radiation forces: Classical theory and recent advances,” in Recent Research Developments in Acoustics (Transworld Research Network, Trivandrum, Kerala, India, 2003), Vol. 1, pp. 39-67.
  • A. A. Doinikov, “Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. I. General formula,” J. Acoust. Soc. Am. 101(2), 713-721 (1997).
  • A. A. Doinikov, “Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. II. Force on a rigid sphere,” J. Acoust. Soc. Am. 101(2), 722-730 (1997).
  • A. A. Doinikov, “Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. III. Force on a liquid drop,” J. Acoust. Soc. Am. 101(2), 731-740 (1997).
  • A. A. Doinikov, “Acoustic radiation pressure on a compressible sphere in a viscous fluid,” J. Fluid Mech. 267, 1-21 (1994).
  • A. A. Doinikov, “Acoustic radiation pressure on a rigid sphere in a viscous fluid,” Proc. Royal Soc. London Ser. A 447(1931), 447-466 (1994).